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1

Antifoams: the overlooked additive?

Routledge, Sarah J, Poyner, David R, Bill, Roslyn M

Journal:

Pharmaceutical Bioprocessing

Year:

2014

Language:

english

File:

PDF, 2.71 MB

english, 2014

2

A comparison of SMA (styrene maleic acid) and DIBMA (di-isobutylene maleic acid) for membrane protein purification

Gulamhussein, Aiman A., Uddin, Romez, Tighe, Brian J., Poyner, David R., Rothnie, Alice J.

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

2020

Language:

english

File:

PDF, 3.60 MB

english, 2020

3

Structure–function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors

Tao Qi, Kien Ly, David R. Poyner, George Christopoulos, Patrick M. Sexton, Debbie L. Hay

Journal:

Year:

2011

Language:

english

File:

PDF, 298 KB

english, 2011

4

G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent

Jamshad, Mohammed, Charlton, Jack, Lin, Yu‑Pin, Routledge, Sarah J., Bawa, Zharain, Knowles, Timothy J., Overduin, Michael, Dekker, Niek, Dafforn, Tim R., Bill, Roslyn M., Poyner, David R., Wheatley,

Journal:

Bioscience Reports

Year:

2015

Language:

english

File:

PDF, 922 KB

english, 2015

5

Microbial expression systems for membrane proteins

Dilworth, Marvin V., Piel, Mathilde S., Bettaney, Kim E., Ma, Pikyee, Luo, Ji, Sharples, David, Poyner, David R., Gross, Stephane R., Moncoq, Karine, J. F. Henderson, Peter, Miroux, Bruno, Bill, Rosly

Journal:

Year:

2018

Language:

english

File:

PDF, 2.77 MB

english, 2018

6

Synthesis and iron binding studies of myo-inositol 1,2,3-trisphosphate and (±)-myo-inositol 1,2-bisphosphate, and iron binding studies of all myo-inositol tetrakisphosphates

Ian D. Spiers, Christopher J. Barker, Sung-Kee Chung, Young-Tae Chang, Sally Freeman, John M. Gardiner, Peter H. Hirst, Peter A. Lambert, Robert H. Michell, David R. Poyner, Carl H. Schwalbe, Anthony

Journal:

Carbohydrate Research

Year:

1996

Language:

english

File:

PDF, 1.03 MB

english, 1996

7

The first synthesis and iron binding studies of the natural product, myo-inositol 1,2,3-trisphosphate

Ian D. Spiers, Sally Freeman, David R. Poyner, Carl H. Schwalbe

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 182 KB

english, 1995

8

Oxidation and ring cleavage reactions of 3-benzhydrylchromones. Generation of triarylmethine cations from methylidenechroman-4-ones and benzopyrano[4,3-c]pyrazoles

Christopher D. Gabbutt, Tessa F.L. Hargrove, B. Mark Heron, David Jones, Carley Poyner, Emel Yildiz, Peter N. Horton, Michael B. Hursthouse

Journal:

Year:

2006

Language:

english

File:

PDF, 416 KB

english, 2006

9

Serum anti-mitochondrial antibodies and fatigue in primary biliary cirrhosis

Julia Newton, Elizabeth Poyner, David E. J. Jones

Journal:

Liver International

Year:

2009

Language:

english

File:

PDF, 103 KB

english, 2009

10

The Preclinical Pharmacology of BIBN4096BS, a CGRP Antagonist

Debbie L. Hay, David Poyner

Journal:

Cardiovascular Therapeutics

Year:

2005

Language:

english

File:

PDF, 101 KB

english, 2005

11

The selectivity and structural determinants of peptide antagonists at the CGRP receptor of rat, L6 myocytes

Stephen G Howitt, David R Poyner

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 315 KB

english, 1997

12

Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: studies with chimeric and other peptides

David R Poyner, Ursel Soomets, Stephen G Howitt, Ulo Langel

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 332 KB

english, 1998

13

Characterization of receptors for calcitonin gene-related peptide and adrenomedullin on the guinea-pig vas deferens

David R Poyner, Gillian M Taylor, A Elaine Tomlinson, Alan G Richardson, David M Smith

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 204 KB

english, 1999

14

Comparison of the expression of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines

Tejal Choksi, Debbie L Hay, Stephen Legon, David R Poyner, Stefanie Hagner, Stephen R Bloom, David M Smith

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 242 KB

english, 2002

15

A comparison of the actions of BIBN4096BS and CGRP8–37 on CGRP and adrenomedullin receptors expressed on SK-N-MC, L6, Col 29 and Rat 2 cells

Debbie L Hay, Stephen G Howitt, Alex C Conner, Henri Doods, Marcus Schindler, David R Poyner

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 170 KB

english, 2002

16

The role of the 8-18 helix of CGRP8-37 in mediating high affinity binding to CGRP receptors; coulombic and steric interactions

Stephen G Howitt, Kalle Kilk, Yang Wang, David M Smith, Ulo Langel, David R Poyner

Journal:

British Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 209 KB

english, 2003

17

Characterization and effects on cAMP accumulation of adrenomedullin and calcitonin gene-related peptide (CGRP) receptors in dissociated rat spinal cord cell culture

Mohammad A Takhshid, David R Poyner, Jean-Guy Chabot, Alain Fournier, Weiya Ma, Wen-Hua Zheng, Ali A Owji, Remi Quirion

Journal:

British Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 330 KB

english, 2006

18

The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors

Debbie L. Hay, Alex C. Conner, Stephen G. Howitt, David M. Smith, David R. Poyner

Journal:

Journal of Molecular Neuroscience

Year:

2004

Language:

english

File:

PDF, 149 KB

english, 2004

19

Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function

James Barwell, Alex Conner, David R. Poyner

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2011

Language:

english

File:

PDF, 1.24 MB

english, 2011

20

Modulating receptor function through RAMPs: can they represent drug targets in themselves?

Patrick M. Sexton, David R. Poyner, John Simms, Arthur Christopoulos, Debbie L. Hay

Journal:

Drug Discovery Today

Year:

2009

Language:

english

File:

PDF, 590 KB

english, 2009

21

GPCR modulation by RAMPs

Debbie L. Hay, David R. Poyner, Patrick M. Sexton

Journal:

Pharmacology & Therapeutics

Year:

2006

Language:

english

File:

PDF, 680 KB

english, 2006

22

Sequence and chemistry requirements for a novel aptameric oligonucleotide inhibitor of EGF receptor tyrosine kinase activity

Saghir Akhtar, Debbie Dunnion, David Poyner, John Ackroyd, Mike Bibby, John Double

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 724 KB

english, 2002

23

Multiple receptors for calcitonin gene-related peptide and amylin on guinea-pig ileum and vas deferens

A. Elaine Tomlinson, David R. Poyner

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.07 MB

english, 1996

24

Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?

James Barwell, Joseph J Gingell, Harriet A Watkins, Julia K Archbold, David R Poyner, Debbie L Hay

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 4.88 MB

english, 2012

25

The pharmacology of Adrenomedullin 2/Intermedin

Yanguo Hong, Debbie L Hay, Remi Quirion, David R Poyner

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 821 KB

english, 2012

26

Secretin family (Class B) G protein-coupled receptors – from molecular to clinical perspectives

David R Poyner, Debbie L Hay

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 156 KB

english, 2012

27

A Polymorphism in the Growth Hormone (GH)-Releasing Hormone (GHRH) Receptor Gene Is Associated with Elevated Response to GHRH by Human Pituitary Somatotrophinomas in Vitro

Eric F. Adams, Hedwig Symowski, Michael Buchfelder, David R. Poyner

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 67 KB

english, 2000

28

Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74

Philip S. Miller, James Barwell, David R. Poyner, Mark J. Wigglesworth, Stephen L. Garland, Dan Donnelly

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 389 KB

english, 2010

29

Calcitonin gene-related peptide, adrenomedullin and flushing

Debbie L. Hay, David R. Poyner

Journal:

Year:

2009

Language:

english

File:

PDF, 143 KB

english, 2009

30

Functional characterization of two human receptor activity-modifying protein 3 variants

Richard J. Bailey, Joshua W.I. Bradley, David R. Poyner, Dan L. Rathbone, Debbie L. Hay

Journal:

Year:

2010

Language:

english

File:

PDF, 293 KB

english, 2010

31

Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23–60 of the calcitonin receptor-like receptor

James Barwell, Philip S. Miller, Dan Donnelly, David R. Poyner

Journal:

Year:

2010

Language:

english

File:

PDF, 569 KB

english, 2010

32

Regulation of signal transduction by calcitonin gene-related peptide receptors

Christopher S Walker, Alex C Conner, David R Poyner, Debbie L Hay

Journal:

Trends in Pharmacological Sciences

Year:

2010

Language:

english

File:

PDF, 386 KB

english, 2010

33

The perils of using the human genome sequence: lessons from CALCRL

Alex C Conner, David R Poyner

Journal:

Trends in Pharmacological Sciences

Year:

2001

Language:

english

File:

PDF, 20 KB

english, 2001

34

CGRP receptors: beyond the CGRP1–CGRP2 subdivision?

David Poyner, Ian Marshall

Journal:

Trends in Pharmacological Sciences

Year:

2001

Language:

english

File:

PDF, 21 KB

english, 2001

35

CGRP receptors: a headache to study, but will antagonists prove therapeutic in migraine?

Susan D Brain, David R Poyner, Raymond G Hill

Journal:

Trends in Pharmacological Sciences

Year:

2002

Language:

english

File:

PDF, 97 KB

english, 2002

36

A polymorphism in the growth hormone-releasing hormone receptor gene: Clinical significance?

Eric F Adams, Eftychia Oikonomou, Mandeep Bhamrah, Michael Buchfelder, Rosalind Mitchell, David R Poyner

Journal:

Regulatory Peptides

Year:

2002

Language:

english

File:

PDF, 156 KB

english, 2002

37

Desensitisation of adrenomedullin and CGRP receptors

Debbie L. Hay, David R. Poyner, David M. Smith

Journal:

Regulatory Peptides

Year:

2003

Language:

english

File:

PDF, 169 KB

english, 2003

38

CGRP receptor heterogeneity: a role for receptor component protein?

Debbie L Hay, David Poyner, Ian Dickerson

Journal:

Trends in Endocrinology & Metabolism

Year:

2003

Language:

english

File:

PDF, 58 KB

english, 2003

39

Modulation of the structure-binding relationships of antagonists for muscarinic acetylcholine receptor subtypes

E. Kristina Pedder, Phike Eveleigh, David Poyner, Edward C. Hulme, Nigel J.M. Birdsall

Journal:

British Journal of Pharmacology

Year:

1991

Language:

english

File:

PDF, 1.40 MB

english, 1991

40

Pharmacological characterization of a receptor for calcitonin gene-related peptide on rat, L6 myocytes

David R. Poyner, David P. Andrew, Derek Brown, Christopher Bose, Michael R. Hanley

Journal:

British Journal of Pharmacology

Year:

1992

Language:

english

File:

PDF, 1.38 MB

english, 1992

41

Altering the ribosomal subunit ratio in yeast maximizes recombinant protein yield

Nicklas Bonander, Richard AJ Darby, Ljuban Grgic, Nagamani Bora, Jikai Wen, Saverio Brogna, David R Poyner, Michael AA O'Neill, Roslyn M Bill

Journal:

Microbial Cell Factories

Year:

2009

Language:

english

File:

PDF, 601 KB

english, 2009

42

Characterization of the Structure of RAMP1 by Mutagenesis and Molecular Modeling

Simms, John, Hay, Debbie L., Wheatley, Mark, Poyner, David R.

Journal:

Biophysical Journal

Year:

2006

Language:

english

File:

PDF, 215 KB

english, 2006

43

Synthesis and evaluation of N1-substituted-3-propyl-1,4-benzodiazepine-2-ones as cholecystokinin (CCK2) receptor ligands

Eric Lattmann, Jintana Sattayasai, David C. Billington, David R. Poyner, Prapawadee Puapairoj, Siriporn Tiamkao, Wanchai Airarat, Harjit Singh, Michael Offel

Journal:

Journal of Pharmacy and Pharmacology

Year:

2002

Language:

english

File:

PDF, 291 KB

english, 2002

44

The activation of the CGRP receptor

Barwell, James, Wheatley, Mark, Conner, Alex C., Taddese, Bruck, Vohra, Shabana, Reynolds, Christopher A., Poyner, David R.

Journal:

Biochemical Society Transactions

Year:

2013

Language:

english

File:

PDF, 267 KB

english, 2013

45

The role of the extracellular loops of the CGRP receptor, a family B GPCR

Barwell, James, Woolley, Michael J., Wheatley, Mark, Conner, Alex C., Poyner, David R.

Journal:

Biochemical Society Transactions

Year:

2012

Language:

english

File:

PDF, 358 KB

english, 2012

46

G-Protein-Coupled Receptors: from Structural Insights to Functional Mechanisms

Chini, Bice, Parenti, Marco, Poyner, David R., Wheatley, Mark

Journal:

Biochemical Society Transactions

Year:

2013

Language:

english

File:

PDF, 69 KB

english, 2013

47

CGRP receptor antagonists: design and screening

Poyner, David R, Hay, Debbie L, Conner, Alex C

Journal:

Expert Opinion on Drug Discovery

Year:

2009

Language:

english

File:

PDF, 1.35 MB

english, 2009

48

G Protein-Coupled Receptors || A Disulfide Cross-linking Strategy Useful for Studying Ligand-induced Structural Changes in GPCRs

Poyner, David R., Wheatley, Mark

Year:

2010

Language:

english

File:

PDF, 3.40 MB

english, 2010

49

G Protein-Coupled Receptors || Substituted Cysteine Accessibility Method (SCAM)

Poyner, David R., Wheatley, Mark

Year:

2010

Language:

english

File:

PDF, 604 KB

english, 2010

50

G Protein-Coupled Receptors || Monitoring GPCR-Protein Complexes Using Bioluminescence Resonance Energy Transfer

Poyner, David R., Wheatley, Mark

Year:

2010

Language:

english

File:

PDF, 3.06 MB

english, 2010

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